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KMID : 0043320100330081165
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Archives of Pharmacal Research
2010 Volume.33 No. 8 p.1165 ~ p.1168
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A new isoflavone glycoside from the stem bark of Sophora japonica
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Park Hyun-Young
Kim Soo-Hee
Kim Gi-Beom
Sim Jae-Young
Lim Soon-Sung
Kim Myong-Jo
Chun Wan-Joo
Kwon Yong-Soo
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Abstract
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A new isoflavone glycoside, 6-methoxy-7-hydroxy-4′-O-β-d-glucosyl isoflavone, glycitein-4′-O-β-d-glucoside (10), along with nine known flavonoids, were isolated from the stem bark of Sophora japonica. The structures of these compounds were determined by analysis of spectroscopic data (1D -, 2D - NMR and HRMS). The inhibitory effects of all the isolated compounds on aldose reductase were evaluated in vitro. Among these compounds, daidzein (1), puerol A (4), and paratensein-7-O-glucoside (9) exhibited potent inhibitory effects, with IC50 values of 3.2, 6.4, and 1.9 μM, respectively.
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KEYWORD
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Sophora japonica, Stem bark, Isoflavone glycoside, Glycitein-4′-O-d-glucoside, Aldose reductase
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